Antioch, six miles southeast of Carthage in central Panola County, was established before 1900. A school began operating there around 1900, and in 1906 it had an enrollment of sixty-one. In the mid-1930s the community had a school, a church, a cemetery, and a number of houses. During the 1940s the school was consolidated with the Carthage school, and by the mid-1960s only a cemetery and a few scattered houses remained in the area. However, in 2000 the population was reported at 121.
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