Patterson Settlement was on the Sabinal River six miles south of Sabinal in southeastern Uvalde County. It was founded by and named for G. W. Patterson, Sr., who brought his family homesteading from Alabama to Texas in 1847. The Patterson family arrived in the Sabinal Canyon in 1851 after a stay in East Texas. Shortly after arriving at the site Patterson preempted 160 acres and purchased additional, then built a rock house on the banks of the Sabinal River with the use of slave labor. John Leakey, who later founded Leakey, and A. B. Dillard, who helped found Leona Ditch, may have been among the original settlers of Patterson Settlement.
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