The site of Science Hall, on a hill between Kyle and Buda thirteen miles northeast of San Marcos in Hays County, was settled by the Andrews and Goforth families in 1871. Later that year a community-supported school opened and was named Science Hall. The settlement soon took the school's name. A public school, Science Hall Home Institute, opened in 1876 with thirty students. In 1885 Mrs. Willie A. Andrews opened a girls' boarding school, known as the Science Hall Home Institute, in her home. In the early 1890s the town supported a short-lived post office, a cotton gin, a store, and a blacksmith. There has been no recorded community center at Science Hall in the twentieth century.
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